Skip to main content

Advertisement

SpringerLink
Log in

Surgical Outcomes of Isolated Malignant Pulmonary Nodules in Patients with a History of Breast Cancer

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The role of surgery for isolated malignant pulmonary nodules in breast cancer patients remains unclear.

Methods

A total of 1286 consecutive breast cancer patients with pulmonary nodules detected by thoracic computed tomography (CT) or positron emission tomography (PET)/CT scan at Shanghai Cancer Center, Fudan University, were reviewed. Overall, 147 breast cancer patients with isolated malignant pulmonary nodules receiving surgery and/or chemotherapy were enrolled in the study. Patients were classified into three groups: patients with primary lung cancer (PLC) receiving surgery (Group 1), patients with lung metastasis receiving surgery (Group 2), and patients with lung metastasis receiving chemotherapy (Group 3). Survival outcomes, including overall survival (OS) and progression-free survival (PFS), were analyzed for patients in all three groups, and prognostic factors for PFS for patients with pulmonary metastasis were evaluated.

Results

Patients with PLC receiving surgery had better survival outcomes, including OS and PFS, than patients with lung metastases who received surgical resection. Breast cancer patients with solitary lung metastasis who received metastasectomy had a significantly better PFS than those who did not; however, no statistically significant difference in OS was observed between the two groups. A multivariate analysis conducted in patients with isolated metastatic breast cancer showed that surgery was an independent factor for better PFS.

Conclusions

Surgery should be considered a valid option for the diagnosis and treatment of breast cancer patients presenting with isolated malignant lung nodules.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Rashid OM, Takabe K. The evolution of the role of surgery in the management of breast cancer lung metastasis. J Thoracic Dis. 2012;4(4):420–24.

    PubMed  PubMed Central  Google Scholar 

  2. Chang EY, Johnson W, Karamlou K, et al. The evaluation and treatment implications of isolated pulmonary nodules in patients with a recent history of breast cancer. Am J Surg. 2006;191(5):641–45.

    Article  PubMed  Google Scholar 

  3. Jeong YJ, Yi CA, Lee KS. Solitary pulmonary nodules: detection, characterization, and guidance for further diagnostic workup and treatment [in Spanish; published erratum appears in Radiologia. 2008;50(4):347]. Radiologia. 2008;50(3):183–95.

    Article  CAS  PubMed  Google Scholar 

  4. Tennis M, Singh B, Hjerpe A, et al. Pathological confirmation of primary lung cancer following breast cancer. Lung Cancer. 2010;69(1):40–45.

    Article  CAS  PubMed  Google Scholar 

  5. Mariotto AB, Rowland JH, Ries LA, Scoppa S, Feuer EJ. Multiple cancer prevalence: a growing challenge in long-term survivorship. Cancer Epidemiol Biomark Prev. 2007;16(3):566–71.

    Article  Google Scholar 

  6. Lorigan P, Califano R, Faivre-Finn C, Howell A, Thatcher N. Lung cancer after treatment for breast cancer. Lancet Oncol. 2010;11(12):1184–92.

    Article  PubMed  Google Scholar 

  7. Nakagiri T, Sawabata N, Funaki S, et al. Validation of pN2 sub-classifications in patients with pathological stage IIIA N2 non-small cell lung cancer. Interact Cardiovasc Thorac Surg. 2011;12(5):733–38.

    Article  PubMed  Google Scholar 

  8. Whitson BA, Groth SS, Duval SJ, Swanson SJ, Maddaus MA. Surgery for early-stage non-small cell lung cancer: a systematic review of the video-assisted thoracoscopic surgery versus thoracotomy approaches to lobectomy. Ann Thorac Surg. 2008;86(6):2008–2016; discussion 2016–2008.

    Article  PubMed  Google Scholar 

  9. Kassis ES, Vaporciyan AA. Defining N2 disease in non-small cell lung cancer. Thorac Surg Clin. 2008;18(4):333–37.

    Article  PubMed  Google Scholar 

  10. Ye T, Yang B, Tong H, Zhang Y, Xia J. Long-term outcomes of surgical resection for liver metastasis from breast cancer. Hepato-gastroenterology. 2015;62(139):688–92.

    PubMed  Google Scholar 

  11. Friedel G, Pastorino U, Ginsberg RJ, et al. Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases. Eur J Cardio-thorac Surg. 2002;22(3):335–44.

    Article  Google Scholar 

  12. Gooi BH, Premnath N, Manjit S. Pulmonary resection for metastatic breast cancer. Med J Malays. 2004;59(1):112–14.

    CAS  Google Scholar 

  13. Ludwig C, Stoelben E, Hasse J. Disease-free survival after resection of lung metastases in patients with breast cancer. Eur J Surg Oncol. 2003;29(6):532–35.

    Article  CAS  PubMed  Google Scholar 

  14. Tanaka F, Li M, Hanaoka N, et al. Surgery for pulmonary nodules in breast cancer patients. Ann Thorac Surg. 2005;79(5):1711–14.

    Article  PubMed  Google Scholar 

Download references

Acknowledgement

The authors would like to thank Emeritus Professor Jean Deslauriers, Laval University, Canada, for his instruction of this study and assistance with language revision.

Disclosure

Zuodong Song, Ting Ye, Longfei Ma, Jiaqing Xiang, and Haiquan Chen declare that they have no conflicts of interest.

Author information

Author notes

  1. Zuodong Song and Ting Ye have contributed equally to this work.

Authors and Affiliations

  1. Department of Thoracic Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China

    Zuodong Song MD, Ting Ye MD, PhD, Longfei Ma MD, Jiaqing Xiang MD, PhD & Haiquan Chen MD, PhD

  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

    Zuodong Song MD, Ting Ye MD, PhD, Longfei Ma MD, Jiaqing Xiang MD, PhD & Haiquan Chen MD, PhD

Authors
  1. Zuodong Song MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ting Ye MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Longfei Ma MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jiaqing Xiang MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Haiquan Chen MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Jiaqing Xiang MD, PhD or Haiquan Chen MD, PhD.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Song, Z., Ye, T., Ma, L. et al. Surgical Outcomes of Isolated Malignant Pulmonary Nodules in Patients with a History of Breast Cancer. Ann Surg Oncol 24, 3748–3753 (2017). https://doi.org/10.1245/s10434-017-6067-0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1245/s10434-017-6067-0

Keywords

Search

Navigation