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Can intra-operative intraperitoneal free cancer cell detection techniques identify patients at higher recurrence risk following curative colorectal cancer resection: a meta-analysis

  • Gastrointestinal Oncology
  • Original Papers
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Accurate staging of colorectal cancer is important for predicting prognosis and guiding treatment. This study uses meta-analysis to investigate if the pre- or post-resection detection of intraperitoneal free cancer cells can predict recurrence in patients undergoing curative colorectal cancer surgery.

Methods

A literature search was performed on all studies between January 1990 and July 2007 comparing the detection of intraperitoneal free cancer cells either pre- or post-resection with prognosis in colorectal cancer. The following prognostic outcomes were meta-analyzed: overall recurrence rate and local recurrence rate. A random-effect model was used and heterogeneity was assessed.

Results

Nine studies reporting on a total of 1182 subjects matched the selection criteria. Free cancer cells were detected prior to tumor resection in 125/822 (15.2%) of patients and following resection in 64/533 (12%) of patients. Preresection, the absence of tumor cells was associated with a lower overall recurrence (25.2%) compared to the presence of tumor cells [46.4%, odds ratio (OR) = 0.41, confidence interval (CI) 0.19–0.88]; as well as a significantly lower local recurrence (12.2% versus 21.1%, OR = 0.42, CI 0.21–0.82). Postresection, the absence of tumor cells also resulted in significantly lower overall recurrence (17.3%) when compared to the presence of tumor cells (52.6%, OR = 0.07, CI 0.03–0.18).

Conclusions

The detection of intraperitoneal free cancer cells is associated with higher recurrence and poorer prognosis. Use of these techniques can identify patients at higher recurrence risk. This could be particularly valuable in stage II disease to identify patients who may benefit from adjuvant chemotherapy.

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Authors and Affiliations

  1. Department of Biosurgery and Surgical Technology, Imperial College London, St Mary’s Hospital, London, W2 1NY, United Kingdom

    Sushil Rekhraj MSc, MRCS, Omer Aziz BSc, MRCS, Shirish Prabhudesai MS, MRCS, Emmanouil Zacharakis MD, PhD, Franziska Mohr MD, Thanos Athanasiou MD, PhD, FETCS, Ara Darzi MD, FMedSci, HonFREng, KBE & Paul Ziprin MD, FRCS

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  1. Sushil Rekhraj MSc, MRCS
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  2. Omer Aziz BSc, MRCS
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  4. Emmanouil Zacharakis MD, PhD
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  6. Thanos Athanasiou MD, PhD, FETCS
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  7. Ara Darzi MD, FMedSci, HonFREng, KBE
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Correspondence to Sushil Rekhraj MSc, MRCS.

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Rekhraj, S., Aziz, O., Prabhudesai, S. et al. Can intra-operative intraperitoneal free cancer cell detection techniques identify patients at higher recurrence risk following curative colorectal cancer resection: a meta-analysis. Ann Surg Oncol 15, 60–68 (2008). https://doi.org/10.1245/s10434-007-9591-5

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