Skip to main content
SpringerLink
Log in

Topical Delivery of Fenoprofen Calcium via Elastic Nano-vesicular Spanlastics: Optimization Using Experimental Design and In Vivo Evaluation

  • Research Article
  • Published:
AAPS PharmSciTech Aims and scope Submit manuscript

Abstract

The aim of this study was to investigate the potential of surfactant-based nanovesicular system (spanlastics) for topical delivery of fenoprofen calcium (FPCa) to eliminate its oral gastrointestinal adverse effects. FPCa-loaded spanlastics were prepared by thin film hydration (TFH) technique according to a full factorial design to investigate the influence of formulation variables on the drug entrapment efficiency (%EE), particle size (PS), deformability index (DI), and the % drug released after 24 h through the cellulose membrane (Q24h) using Design-Expert® software. The optimized formula (composed of Span 60 and Tween 60 as an edge activator at weight ratio of 8: 2 in presence of Transcutol P as a cosolvent in the hydration media) exhibited the highest %EE (49.91 ± 2.60%), PS of 536.1 ± 17.14 nm, DI of 5.07 ± 0.06 g, and Q24h of 61.11 ± 2.70%; it was also characterized for morphology and physical stability. In vitro release study of FPCa-loaded spanlastic gel and conventional FPCa gel through a synthetic membrane and hairless rat skin were evaluated. The skin permeation study revealed that spanlastic gel exhibited both consistent and prolonged action. Finally, the % inhibition of carrageenan-induced rat paw edema of spanlastic gel was three times higher than the conventional FPCa gel after 24 h. In conclusion, spanlastic-based gel could be a great approach for improving topical delivery of fenoprofen calcium, providing both prolonged and enhanced anti-inflammatory activity in the treatment of arthritis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

REFERENCES

  1. Sweetman SC, editor. Martindale: the complete drug reference. 37th ed. London: Pharmaceutical Press; 2011.

    Google Scholar 

  2. Idrees MA, Rahman NU, Ahmad S, Ali MY, Ahmad I. Enhance transdermal delivery of flurbiprofen via microemulsions: effects of different types of surfactants and cosurfactants. J DARU. 2011;19(6):433–9.

    CAS  Google Scholar 

  3. Marianecci C, Di Marzio L, Rinaldi F, Celia C, Paolino D, Alhaique F, Esposito S, Carafa M. Niosomes from 80s to present: the state of the art. Adv Colloid Interf Sci. 2014;205:187–206.

    Article  CAS  Google Scholar 

  4. Cevc G, Mazgareanu S, Rother M. Preclinical characterisation of NSAIDs in ultradeformable carriers or conventional topical gels. Int J Pharm. 2008;360:29–39.

    Article  CAS  PubMed  Google Scholar 

  5. Kakkar S. Indu pal Kaur. Spanlastics—a novel nanovesicular carrier system for ocular delivery. Int J Pharm. 2011;413:202–10.

    Article  CAS  PubMed  Google Scholar 

  6. Mahale NB, Thakkar PD, Mali RG, Walunj DR, Chaudhari SR. Niosomes: novel sustained release nonionic stable vesicular systems —an overview. Adv Colloid Interf Sci. 2012;183–184:46–54.

    Article  Google Scholar 

  7. Kumar GP, Rajeshwarrao P. Nonionic surfactant vesicular systems for effective drug delivery—an overview. Acta Pharm Sin B. 2011;1(4):208–19.

    Article  Google Scholar 

  8. Choi MJ, Maibach HI. Elastic vesicles as topical/transdermal drug delivery systems. Int J Cosmetic Science. 2005;27:211–21.

    Article  CAS  Google Scholar 

  9. Basha M, El-Alim SHA, Shamma RN, Awad GE. Design and optimization of surfactant-based nanovesicles for ocular delivery of clotrimazole. J Liposome Res. 2013; doi:10.3109/08982104.2013.788025.

    Google Scholar 

  10. Abdulaziz Mohsen Al-Mahallawi, Omneya Mohammed Khowessah, Raguia Ali Shoukri. Ciprofloxacin-loaded Spanlastics for Ototopical Non-invasive Delivery to the Middle Ear: In-vitro and Ex-vivo Studies. Inventi Impact NDDS. 2014;(3).

  11. Shinde UA, Kanojiya SS. Serratiopeptidase Niosomal gel with potential in topical delivery. J Pharm (Cairo). 2014;2014:382959. doi:10.1155/2014/382959.

    Google Scholar 

  12. Alia A. Badawi, Nabaweya Abd el-aziz, Maha M. Amin, Nermin M. Sheta. Topical Benzophenone-3 microemulsion-based gels: preparation, evaluation and determination of microbiological UV blocking activity. Int J Pharm Pharm Sci. 2014;6(8):562–70.

    Google Scholar 

  13. Hao Y, Zhao F, Li N, Yang Y, Li K. Studies on a high encapsulation of colchicine by a noisome system. Int J Pharm. 2002;244(1–2):73–80.

    Article  CAS  PubMed  Google Scholar 

  14. Jigar V, Puja V, Dhaval R, Paresh P. Development of topical Niosomal gel of benzoyl peroxide. ISRN Nanotechnology. 2011;2011:Article ID 503158. doi:10.5402/2011/503158.6 pages

    Google Scholar 

  15. Jigar V, Puja V, Krutika S. Formulation and evaluation of topical niosomal gel of erythromycin. Int J Pharm Pharm Sci. 2011;3(1):123–6.

    Google Scholar 

  16. Arunothayanun P, Bernard MS, Criag DQ, Uchegbu IF, Florence AT. The effect of processing variables on the physical characteristics of non-ionic surfactant vesicles (niosomes) formed from hexa-decyl diglycerol ether. Int J Pharm. 2000;201(1):7–14.

    Article  CAS  PubMed  Google Scholar 

  17. Abdelbary G, El-Gendy N. Niosome-encapsulated gentamicin for ophthalmic controlled delivery. AAPS PharmSciTech. 2008;9:740–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Mehanna MM, Motawaa AM, Samaha MW. Nanovesicular carrier-mediated transdermal delivery of tadalafil: formulation and physicsochemical characterization. J Drug Dev Ind Pharm. 2015;41(5):714–21. doi:10.3109/03639045.2014.900075.

    Article  CAS  Google Scholar 

  19. Kazi KM, Mandal AS, Biswas N, Guha A, Chatterjee S, Behera M, Kuotsu K. Niosome: A future of targeted drug delivery systems. J Adv Pharm Technol Res. 2010;1(4):374–80. doi:10.4103/0110-5558.76435.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Sandeep G, Vasavi Reddy D. Srinivas Reddy Devireddy. Formulation and evaluation of fluconazole pro-Niosomal gel for topical administration. J App Pharm Sci. 2014;4(07):098–104.

    Google Scholar 

  21. Panwar P, Pandey B, Lakhera PC, Singh KP. Preparation, characterization and in-vitro release study of albendazole-encapsulated nano-size liposomes. Int J Nanomedicine. 2010;5:101–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Gaafar PME, Abdallah OY, Farid RM, Abdelkader H. Preparation, characterization and evaluation of novel elastic nano-sized niosomes (ethoniosomes) for ocular delivery of prednisolone. J Liposome Res. 2014;24(3):204–15. doi:10.3109/08982104.2014.881850.

    Article  CAS  PubMed  Google Scholar 

  23. Agrawal R, Sandhu SK, Sharma I, Kaur IP. Development and evaluation of Curcumin-loaded elastic vesicles as an effective topical anti-inflammatory formulation. AAPS PharmSciTech. 2015;16(2):364–74. doi:10.1208/s12249-014-0232-6.

    Article  CAS  PubMed  Google Scholar 

  24. Ioele G, Tavano L, De Luca M, Ragno G, Picci N, Muzzalupo R. Photostability and ex-vivo permeation studies on diclofenac in topical niosomal formulations. Int J Pharm. 2015;494:490–7.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutics, The Applied Research Center of Medicinal Plants “ARCMP”, National Organization for Drug Control and Research “NODCAR”, El-Mansouria Road, El-Haram, Giza, Egypt

    Dalia Ali Farghaly

  2. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini St, Cairo, 11562, Egypt

    Ahmed A. Aboelwafa & Magdy I. Mohamed

  3. Department of Pharmaceutics, National Organization for Drug Control and Research “NODCAR”, 51 Wezaret El-Zeraa St., Agouza, Giza, Egypt

    Manal Y. Hamza

Authors
  1. Dalia Ali Farghaly
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ahmed A. Aboelwafa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Manal Y. Hamza
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Magdy I. Mohamed
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dalia Ali Farghaly.

Ethics declarations

All animal procedures are in accordance to the guidelines of the ‘Principles of Laboratory Animal Care’ and were approved by the Ethics Committee of Animal Care of the Faculty of Pharmacy, Cairo University, Egypt.

Conflict of interest

The authors declare that they have no conflicts of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Farghaly, D.A., Aboelwafa, A.A., Hamza, M.Y. et al. Topical Delivery of Fenoprofen Calcium via Elastic Nano-vesicular Spanlastics: Optimization Using Experimental Design and In Vivo Evaluation. AAPS PharmSciTech 18, 2898–2909 (2017). https://doi.org/10.1208/s12249-017-0771-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1208/s12249-017-0771-8

Key words

Search

Navigation