ABSTRACT
Encapsulation technologies are nowadays commonly used in pharmaceutical, cosmetic, and medical industries for the development of controlled-release delivery systems [1-4]. Many therapeutically active molecules need to be encapsulated in a drug-carrying system to prevent the loaded drug from degradation but also to ensure its effective delivery in the biological media. Nanoencapsulation may also protect the active compound
CONTENTS
10.1 Introduction ........................................................................................................................225 10.2 Materials and Methods ..................................................................................................... 226
10.2.1 Chemicals .............................................................................................................. 226 10.2.2 Preparation of Lipid Nanoparticles Loaded with Actives .............................227 10.2.3 Preparation of the Inclusion Complexes ...........................................................227 10.2.4 Entrapment Efciency (EE%)..............................................................................228 10.2.5 Micro-Raman Spectroscopy ...............................................................................228 10.2.6 SEM and AFM Imaging ......................................................................................228 10.2.7 1H NMR Studies ...................................................................................................228 10.2.8 Controlled Release ...............................................................................................229 10.2.9 Support Film Modication with LNs and CNs ...............................................229 10.2.10 X-Ray Photoelectron Spectroscopy Analysis ...................................................229 10.2.11 Elastic Measurements .......................................................................................... 229
10.3 Results and Discussion .....................................................................................................230 10.3.1 Drug Incorporation and Loading Capacity .....................................................230 10.3.2 Morphological Characterization of LNs and CNs ..........................................230 10.3.3 Characterization of DMy-CDs ........................................................................... 231 10.3.4 Dissolution and Stability Studies ......................................................................234 10.3.5 Chemical and Elastic Characterization of the Engineered Materials ..........235 10.3.6 Drug Delivery Results .........................................................................................236
