Effects of Hydrated Forms of C₆₀ Fullerene on Amyloid β-Peptide Fibrillization In Vitro and Performance of the Cognitive Task

It has been shown for the first time by transmission electron microscopy that the hydrated fullerene C₆₀ inhibited the fibrillization of amyloid-β _25–35 peptide. The fullerene affected the amyloid-β _25–35 assembly, manifesting its anti-amyloidogenic capacity. Our in vivo investigations demonstrated also that a single intracerebroventricular injection of the C₆₀ hydrated fullerene at a dose of 7.2 nmol/ventricle significantly improved the performance of the cognitive task in control rats. The intracerebroventricular injection of the C₆₀ hydrated fullerene (3.6 nmol/ventricle) prevented the impairment of performance of the cognitive task induced by amyloid-β _25–35 (22.5 nmol/ventricle). The results obtained may be useful in the development of therapy of Alzheimer's disease.