Physically Modified Bacterial Cellulose as Alternative Routes for Transdermal Drug Delivery

Bacterial cellulose (BC) has established to be a remarkably versatile biomaterial and can be used in wide variety of applied scientific endeavors, especially for medical devices. In fact, biomedical devices recently have gained a significant amount of attention because of increased interesting tissue-engineered products for both wound care and the regeneration of damaged or diseased organs. The architecture of BC materials can be engineered over length scales ranging from nano to macro by controlling the biofabrication process, besides, surface modifications bring a vital role in in vivo performance of biomaterials. This work highlights the potential of gamma irradiation treatment for the modification of the BC surface properties, enhancing its potential for biomedical applications. Samples did not show significant variation in thermal properties, however, higher density of porous were produced in irradiated samples than non irradiated which produced slowly diffusion than nonirradiated membrane.