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Synthesis of magnetite hydrosols and assessment of their impact on living systems at the cellular and tissue levels using MRI and morphological investigation

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Abstract

MRI and morphological investigations into internal organ tissues and tumors in rats with liver cancer PC-1 under the intraperitoneal administration of magnetite hydrosols have been performed. The absence of any toxic effect of magnetite nanoparticles at low concentrations (0.325 mg/mL) has been determined using neutrophil granulocytes. A technique for the synthesis of citrate-stabilized magnetite hydrosols by the coprecipitation of Fe2+ and Fe3+ salts is described. Their electrokinetic potential is −32 ± 2 mV at pH 6.5 ± 0.1. The size distribution of magnetite nanoparticles is obtained by dynamic light scattering. The average size of magnetite nanoparticles is 23 ± 6 nm. The absorption spectra of magnetite hydrosols have been measured. The dependence of the optical density on the concentration has also been obtained. Molar absorption coefficients of magnetite nanoparticles have been calculated at the following wavelengths: 532, 633, 660, and 785 nm.

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Authors and Affiliations

  1. Chernyshevskii State University, ul. Astrakhanskaya 83, Saratov, 410012, Russia

    S. V. German, O. A. Inozemtseva, E. K. Volkova & D. A. Gorin

  2. Saratov Medical State University, ul. B. Kazach’ya 112, Saratov, 410012, Russia

    N. A. Navolokin, V. V. Zuev, A. B. Bucharskaya & G. N. Maslyakova

  3. Nizhni Novgorod Technical State University, ul. Minina 24, Nizhni Novgorod, 603950, Russia

    E. E. Pudovkina & S. N. Pleskova

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  1. S. V. German
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Correspondence to D. A. Gorin.

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Original Russian Text © S.V. German, O.A. Inozemtseva, N.A. Navolokin, E.E. Pudovkina, V.V. Zuev, E.K. Volkova, A.B. Bucharskaya, S.N. Pleskova, G.N. Maslyakova, D.A. Gorin, 2013, published in Rossiiskie Nanotekhnologii, 2013, Vol. 8, Nos. 7–8.

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German, S.V., Inozemtseva, O.A., Navolokin, N.A. et al. Synthesis of magnetite hydrosols and assessment of their impact on living systems at the cellular and tissue levels using MRI and morphological investigation. Nanotechnol Russia 8, 573–580 (2013). https://doi.org/10.1134/S1995078013040034

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