Abstract
Metrological assurance has been developed and formed for a promising technique for measuring the mass fraction and number concentration of nanoparticles containing silver or zinc in different media, including those of a biological nature, i.e., the gamma-ray spectroscopy of neutron-activated samples along with dynamic light scattering. The advantage of this complex measurement technique over other approaches to analytically controlling nanomaterials is discussed. The certified reference materials and standard guides developed in order to ensure the uniformity and traceability of measurements are described. The technique is tested in experiments on the kinetics of accumulation and removal of silver nanoparticles in different organs and excrement of laboratory rats.
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References
Nanomaterials—Toxicity, Health and Environmental Issues, Ed. by C. S. S. R. Kumar (Wiley-VC, 2006).
G. Aliev, J. Daza, A. Lipsitt, et al., “Silver nanoparticles as alternate strategies for drug delivery to Alzheimer brain. Alzheimer’s & Dementia,” J. Alzheimer’s Assoc. 5(4), 324 (2009).
R. A. Kuznetsov, Activation Analysis (Atomizdat, Moscow, 1974) [in Russian].
Yu. P. Buzulukov, I. V. Gmoshinskii, V. F. Demin, N. S. Marchenkov, and R. V. Raspopov, “Experimental researches for pharmakinetics of silver nanoparticles in laboratory rats bodies by using radioactive indicators,” in Proc. 3rd Eurasian Congr. on Medical Physics and Engineering “Medical Physics-2010” (Moscow, June 21–25, 2010), Vol. 3, pp. 238–239.
R. V. Raspopov, Yu. P. Buzulukov, V. F. Demin, et al., “Bioaccessibility of Zh oxide particles. The way to research by the means of radioactive indicators,” Vopr. Pitan. 79(6), 14–18 (2010).
V. K. Mazo and E. A. Egorova, Essentiald Microelements in Nutrition and Norms for Intake (Scientific Research Institute of Nutrition of the Russian Academy of Medical Sciences). http://www.gastroportal.ru
A. V. Skal’nyi, Chemical Elements in Men’s Ecology and Physiology (ONIKS 21 Vek, Moscow, 2004) [in Russian].
G. D. Bothun, “Hydrophobic silver nanoparticles trapped in lipid bilayers: Size distribution, bilayer phase behavior, and optical properties,” J. Nanobiotechnol. 6(13), 1–10 (2008).
SanPiN (Sanitary Regulations) no. 2.6.1.2523-09: Regulations for Radiation Safety (2009).
ASTM E 2490-08: Standard Guide for Measurement of Particle Size Distribution of Nanomaterials in Suspension by Photon Correlation Spectroscopy (PCS) (2008).
ISO 13321:1996(E): Particle Size Analysis—Photon Correlation Spectroscopy (1996).
ISO 22412:2008: Particle Size Analysis—Dynamic Light Scattering (2008).
M. A. Dobrovolskaia, et al., “Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles,” Nanomed: Nanotechnol., Biol. Med. 5(2), 106–117 (2009).
A. D. Levin, A. I. Nagaev, E. M. Rukin, Yu. M. Sadagov, and A. V. Aseichev, “Some problems on methodological supply for biomedical nanotechnologoes,” Izmerit. Tekhn., No. 8, 29–34 (2010).
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Original Russian Text © V.A. Demin, V.F. Demin, Yu.P. Buzulukov, P.K. Kashkarov, A.D. Levin, 2013, published in Rossiiskie Nanotekhnologii, 2013, Vol. 8, Nos. 5–6.
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Demin, V.A., Demin, V.F., Buzulukov, Y.P. et al. Formation of certified reference materials and standard measurement guides for development of traceable measurements of mass fractions and sizes of nanoparticles in different media and biological matrixes on the basis of gamma-ray and optical spectroscopy. Nanotechnol Russia 8, 347–356 (2013). https://doi.org/10.1134/S1995078013030051
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DOI: https://doi.org/10.1134/S1995078013030051