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The role of noradrenalin in the pathogenesis of primary headaches

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Abstract

This review is focused on the role of noradrenalin and its receptors in the pathogenesis of primary headaches, in particular, migraine headaches. The data are summarized on the involvement of different adrenoreceptors in the regulation of tone of cerebral vessels and modulation of transmission of nociceptive information in the trigeminovascular system and at the supraspinal level of the CNS. We discuss the pharmacodynamics of several adrenergic drugs that are used for prophylactic treatment of migraine headaches.

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    A. Y. Sokolov, O. A. Lyubashina & S. S. Panteleev

  2. Valdman Institute of Pharmacology, First Pavlov State Medical University, St. Petersburg, Russia

    A. Y. Sokolov & S. S. Panteleev

  3. Department of Neurology and Neurosurgery, First Pavlov State Medical University, St. Petersburg, Russia

    A. V. Amelin

  4. nab. Makarova 6, St. Petersburg, 199034, Russia

    A. Y. Sokolov

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  1. A. Y. Sokolov
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  2. O. A. Lyubashina
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  3. A. V. Amelin
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  4. S. S. Panteleev
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Original Russian Text © A.Y. Sokolov, O.A. Lyubashina, A.V. Amelin, S.S. Panteleev, 2013, published in Neirokhimiya, 2013, Vol. 30, No. 4, pp. 289–300.

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Sokolov, A.Y., Lyubashina, O.A., Amelin, A.V. et al. The role of noradrenalin in the pathogenesis of primary headaches. Neurochem. J. 7, 256–265 (2013). https://doi.org/10.1134/S1819712413040090

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