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Biocompatible Magnetic Hydrogel Nanocomposite Based on Carboxymethylcellulose: Synthesis, Cell Culture Property and Drug Delivery

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Abstract

In this report, the synthesis of a novel biocompatible magnetic hydrogel nanocomposite based on carboxymethyl cellulose (CMC), as an eco-friend, biocompatible and green polysaccharide, is described via a facile one pot approach using magnetic iron oxide nanoparticles (MIONs) as a crosslinker. The structure of the prepared MION–CMC hydrogel nanocomposite was examined by various analytical techniques such as FTIR spectroscopy, TGA thermal analysis, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The MIONs were generated in situ during the hydrogel formation with an average diameter size of 10 nm and a narrow size distribution. The sample was superparamagnetic with large saturation magnetization at room temperature. MION–CMC hydrogel nanocomposite showed a good ability for releasing of doxorubicin as an anticancer drug at pH 7 with case II (relaxational) transport mechanism. This outcome demonstrated that MION–CMC hydrogel nanocompositeis an attractive biocompatible candidate for widespread biomedical applications, particularly in controlled drug-targeting delivery.

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Authors and Affiliations

  1. Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran

    M. Kurdtabar & H. Nezam

  2. Department of Chemistry, Payame Noor University, Tehran, 19395-3697, Iran

    G. Rezanejade Bardajee

  3. Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran

    M. Dezfulian

  4. Department of Polymer and Petrochemicals, Standard Research Institute (SRI), Karaj, Iran

    H. Salimi

Authors
  1. M. Kurdtabar
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  2. H. Nezam
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  3. G. Rezanejade Bardajee
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  4. M. Dezfulian
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  5. H. Salimi
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Correspondence to M. Kurdtabar.

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The article is published in the original, supplementary materials are available for this article at 10.1134/S1560090418020021 and are accessible for authorized users.

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Biocompatible Magnetic Hydrogel Nanocomposite Based on Carboxymethylcellulose: Synthesis, Cell Culture Property and Drug Delivery

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Kurdtabar, M., Nezam, H., Rezanejade Bardajee, G. et al. Biocompatible Magnetic Hydrogel Nanocomposite Based on Carboxymethylcellulose: Synthesis, Cell Culture Property and Drug Delivery. Polym. Sci. Ser. B 60, 231–242 (2018). https://doi.org/10.1134/S1560090418020021

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  • DOI: https://doi.org/10.1134/S1560090418020021

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