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Chemical Transformations of Chlorophyll a and Possible Areas for Application of Its Derivatives

  • Selected articles originally published in Russian in Rossiiskii Khimicheskii Zhurnal (Russian Chemistry Journal)
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Abstract

Chemical transformations of chlorophyll a, aimed to develop photosensitizers for the antimicrobial and anticancer therapy, as well as for boron neutron capture therapy, have been considered. Research works on the development of purpurine 18 and its analogues have been presented; derivatives with intensive absorption in the near-infrared region of the spectrum, looking promising for photodynamic anticancer therapy, have been synthesized. A large series of works on the synthesis of N-hydroxy and N-amino cycloimides of chlorin p6 have been carried out. Carbohydrate derivatives of chlorin, containing the indicated fragments in various positions of the macrocycle, have been synthesized. The synthesis of chlorin conjugates with the closo-decaborate fragment and bis-dicarbollide of cobalt has been performed. The methods of 1,3-dipolar cycloaddition and the Sonogashira reaction have been used to obtain these conjugates. Chlorin-fullerene conjugates, including water-soluble derivatives, have been synthesized and their spectral and other physicochemical properties have been studied.

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Funding

This work is supported by grants of the President of the Russian Federation “Leading Scientific Schools of the Russian Federation” (grant no. NSh-7946.2016.11) and the Russian Science Foundation (grant no. 16-13-10092).

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  1. Institute of Fine Chemical Technologies, Russian Technological University, pr. Vernadskogo 86, Moscow, 119571, Russia

    A. F. Mironov

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Russian Text © The Author(s), 2017, published in Rossiiskii Khimicheskii Zhurnal, 2017, Vol. 61, No. 3, pp. 42–68.

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Mironov, A.F. Chemical Transformations of Chlorophyll a and Possible Areas for Application of Its Derivatives. Russ J Gen Chem 89, 1952–1983 (2019). https://doi.org/10.1134/S1070363219090354

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