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Efficient Synthesis and Reactions of New Functionally Substituted Pyrido[2,3-d]pyrimidine Candidates

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Abstract

Pyrido[2,3-d]pyrimidine derivatives were synthesized by the reaction of 2-hydrazinopyrido[2,3-d]-pyrimidin-4(3H)-one with different aryl aldehydes and active methylene compounds. Their structures were characterized by spectroscopic methods.

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References

  1. Anwar, M.M., Perez-Leal, O., Rico, M.C., Gordon, J., Bichenkov, E., Mateo, G., Kassem, E.M., Hegazy, G.H., Abou-Gharbia, M., and Childers, W., Bioorg. Med. Chem. Lett., 2017, vol. 27, p. 3117. doi 10.1016/j.bmcl.2017.05.044

    Article  CAS  PubMed  Google Scholar 

  2. Xiamuxi, H., Wang, Z., Li, J., Wang, Y., Wu, C., Yang, F., Jiang, X., Liu, Y., Zhao, Q., Chen, W., Zhang, J., Xie, Y., Hu, T., Xu, M., Guo, S., Akber Aisa, H., He, Y., and Shen, J., Bioorg. Med. Chem., 2017, vol. 25, p. 4904. doi 10.1016/j.bmc.2017.07.040

    Article  CAS  PubMed  Google Scholar 

  3. Yu, L., Huang, M., Xu, T., Tong, L., Yan, XE., Zhang, Z., Xu, Y., Yun, C., Xie, H., Ding, K., and Lu, X., Eur. J. Med. Chem., 2017, vol. 126, p. 1107. doi 10.1016/j.ejmech.2016.12.006

    Article  CAS  PubMed  Google Scholar 

  4. Camarasa, M., Puig de la Bellacasa, R., González, À.L., Ondoño, R., Estrada, R., Franco, S., Badia, R., Esté J., Martínez, M.Á., Teixidó, J., Clotet, B., and Borrell, J.I., Eur. J. Med. Chem., 2016, vol. 115, p. 463. doi 10.1016/j.ejmech.2016.03.055

    Article  CAS  PubMed  Google Scholar 

  5. Hou, J., Wan, S., Wang, G., Zhang, T., Li, Z., Tian, Y., Yu, Y., Wu, X., and Zhang J., Eur. J. Med. Chem., 2016, vol. 118, p. 276. doi 10.1016/j.ejmech.2016.04.026

    Article  CAS  PubMed  Google Scholar 

  6. Naresh, K.R., Jitender, D.G, Ravikumar, N., Krishna, S.D., Debanjan, B., Bharath, G., Narsaiah, B., Nishant, J.S, and Gangagni, R.A., Bioorg. Med. Chem. Lett., 2016, vol. 26, p. 2927. doi 10.1016/j.bmcl.2016.04.038

    Article  CAS  Google Scholar 

  7. Fares, M., Abou-Seri, S.M., Abdel-Aziz, H.A., Abbas, S.E.-S., and Eladwy, A.R., Eur. J. Med. Chem., 2014, vol. 83, p. 155. doi 10.1016/j.ejmech.2014.06.027

    Article  CAS  PubMed  Google Scholar 

  8. Al-Omar, M.A., Khalifa, N.M., and Amr, A.E., Russ. J. Gen. Chem., 2017, vol. 87, no. 10, p. 2467. doi 10.1134/S1070363217100309

    Article  CAS  Google Scholar 

  9. Khalifa, N.M., Al-Omar, M.A., and Amr, A.E., Russ. J. Gen. Chem., 2017, vol. 87, no. 7, p. 1618. doi 10.1134/S1070363217070271

    Article  CAS  Google Scholar 

  10. Khalifa, N.M., Nossier, E.S., Al-Omar, M.A., and Amr, A.E., Russ. J. Gen. Chem., 2016, vol. 86, no. 8, p. 1948. doi 10.1134/S1070363216080284

    Article  CAS  Google Scholar 

  11. Khalifa, N.M., Al-Omar, M.A., Amr, A.E., Baiuomy, A.R., and Abdel-Rahman, R.F., Russ. J. Bioorg. Chem., 2015, vol. 41, no. 2, p. 192. doi 10.1134/S1068162015020090

    Article  CAS  Google Scholar 

  12. Khalifa, N.M., Abdel-Rahman, A.H., Abd-Elmoez, S.I., Fathalla, O.A., and Abd El-Gwaad, A.A., Res. Chem. Intermed., 2015, vol. 41, p. 2295. doi 10.1007/s11164-013-1347-1

    Article  CAS  Google Scholar 

  13. Haiba, M.E., Al-Abdullah, E.S., Edrees, M.M., and Khalifa N.M., Drug Res., 2015, vol. 65, p. 9. doi 10.1055/s-0034-1368721

    CAS  Google Scholar 

  14. Ismail M.F., Khalifa, N.M, Fahmy, H.H., Nossier, E.S., and Abdulla, M.M., J. Heterocyc. Chem., 2014, vol. 51, p. 450. doi 10.1002/jhet.1757

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Khalifa

  2. Therapeutical Chemistry Department, Pharmaceutical and Drug Industries Division, National Research Centre, Cairo, Dokki, 12622, Egypt

    N. M. Khalifa

  3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt

    E. S. Nossier

  4. Applied Organic Chemistry Department, National Research Centre, Cairo, Dokki, 12622, Egypt

    A. E. Amr

Authors
  1. N. M. Khalifa
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  2. E. S. Nossier
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  3. A. E. Amr
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Corresponding author

Correspondence to N. M. Khalifa.

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The text was submitted by the authors in English.

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Khalifa, N.M., Nossier, E.S. & Amr, A.E. Efficient Synthesis and Reactions of New Functionally Substituted Pyrido[2,3-d]pyrimidine Candidates. Russ J Gen Chem 88, 1228–1231 (2018). https://doi.org/10.1134/S1070363218060300

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  • DOI: https://doi.org/10.1134/S1070363218060300

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