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Modification of Polymyxin B1 by Water-Soluble Functional Copolymers of Vinyl Alcohol

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Abstract

The condensation of the peptide antibiotic Polymyxin В1 with the vinyl alcohol copolymers containing aldehyde groups was studied. The structure and composition of the resulting conjugates were determined. The polymer derivatives of the antibiotic were shown to preserve their antimicrobial activity.

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References

  1. Altikatoglu, M., Arioz, C., Basaran, Y., and Zuzu, H., Cent. Eur. J. Chem., 2009, vol. 7, no. 3, p. 423. doi 10.2478/s11532-009-0041-z

    CAS  Google Scholar 

  2. Handley, D.A. and Lake, Ph., US Patent 5177059, 1993; Chem. Abstr., 1993, vol. 118, p. 1112.

    Google Scholar 

  3. Beckman, S., Minor, R.L., White, C.W., Repine, J.E., Rosen, G.M., and Freeman, B.A., J. Biol. Chem., 1988, vol. 263, no. 14, p. 6884.

    CAS  PubMed  Google Scholar 

  4. Appelmelk, B.J., Su, D., Thijs, B.G., and MacLaren, D.M., Anal. Biochem., 1992, vol. 207, no. 2, p. 311. doi 10.1016/0003-2697(92)90017-2

    Article  CAS  PubMed  Google Scholar 

  5. Clark, R., Olson, K., Fuh, G., Marian, M., Mortensen, D., Teshima, G., Chang, S., Chu, H., Mukku, V., Canova-Davis, E., Somers, T., Cronin, M., Winkler, M., and Wells, J.A., J. Biol. Chem., 1996, vol. 271, no. 36, p. 21969. doi 10.1074/jbs.271.36.21969

    Article  CAS  PubMed  Google Scholar 

  6. Guisan, J.M., Enzyme Microb. Tech., 1988, vol. 10, no. 6, p. 375. doi 10.1016/0141-0229(88)90018-X

    Article  CAS  Google Scholar 

  7. Margel, S. and Rembaum, A., Macromolecules, 1980, vol. 13, no. 1, p. 19. doi 10.1021/ma60073a004

    Article  CAS  Google Scholar 

  8. Hermanson, G.T., Bioconjugate Techniques, San Diego: Academic, 1996, p.112.

    Google Scholar 

  9. Essential Procedure for Clinical Microbiology, Isenberg, H.D., Ed., USA: ASM Press, 1998, p.693.

  10. Antibiotiki–polipeptidy: struktura, funktsiya i biosintez (Polypeptide Antibiotics: Structure, Function, and Biosynthesis), Egorov, N.S., Ed., Moscow: Mosk. Univ., 1987.

  11. Encyclopedia of Polymer Science and Technology, New York: Wiley and Sons, 1971, vol. 15, p.577.

  12. Pritchard, J.G., Poly(vinyl alcohol): Basic Properties and Uses. London, New-York: Gordon and Breach, 1970.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, Bol’shoi pr. V.O. 31, St. Petersburg, 199004, Russia

    V. V. Shalygina, E. N. Vlasova & E. F. Panarin

  2. St. Petersburg State Pharmaceutical Academy, St. Petersburg, Russia

    V. A. Gaydukova & E. P. Anan’eva

  3. Petr Velikii State Polytechnical University, St. Petersburg, Russia

    E. F. Panarin

Authors
  1. V. V. Shalygina
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  2. E. N. Vlasova
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  3. V. A. Gaydukova
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  4. E. P. Anan’eva
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  5. E. F. Panarin
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Corresponding author

Correspondence to V. V. Shalygina.

Additional information

Original Russian Text © V.V. Shalygina, E.N. Vlasova, V.A. Gaydukova, E.P. Anan’eva, E.F. Panarin, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 6, pp. 1014–1019.

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Shalygina, V.V., Vlasova, E.N., Gaydukova, V.A. et al. Modification of Polymyxin B1 by Water-Soluble Functional Copolymers of Vinyl Alcohol. Russ J Gen Chem 88, 1194–1198 (2018). https://doi.org/10.1134/S1070363218060233

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  • DOI: https://doi.org/10.1134/S1070363218060233

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