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Synthesis and characterization of novel pyran and pyranopyrimidines linked 8-hydroxy-7-iodoquinoline-5-sulfonamide derivatives

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Abstract

Several novel 8-hydroxy-7-iodoquinoline-5-sulfonamides bearing pyran and pyrano[2,3-d]pyrimidine derivatives were synthesized via a one-pot base catalyzed cyclocondensation reaction of N-(4-acetylphenyl)-8-hydroxy-7-iodoquinoline-5-sulfonamide with malononitrile and arylaldehydes, followed by heterocyclization of the resulting intermediates with the appropriate reagents such as carbon disulphide, formic acid, thiourea, and formamide.

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Correspondence to N. M. Khalifa.

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Al-Omar, M.A., Khalifa, N.M. & Amr, A.E. Synthesis and characterization of novel pyran and pyranopyrimidines linked 8-hydroxy-7-iodoquinoline-5-sulfonamide derivatives. Russ J Gen Chem 87, 2467–2471 (2017). https://doi.org/10.1134/S1070363217100309

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  • DOI: https://doi.org/10.1134/S1070363217100309

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