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Synthesis and characterization of new pyrazolyl-substituted thiazolidinone, thiazole, and thiazoline candidates

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Abstract

1-(3-Chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazole-4-carbaldehyde was used in preparation of (E)-1-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methylene}thiosemicarbazide. Its following reaction with ethyl bromoacetate, diethyl 2-bromomalonate, phenacyl bromide, and maleic anhydride gave pyrazolyl pharmacophore linked thiazole, thiazoline and thiazolidinone-5-carboxylic acid derivatives.

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Authors and Affiliations

  1. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Khalifa & M. A. Al-Omar

  2. Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki, Cairo, 12622, Egypt

    N. M. Khalifa

  3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt

    E. S. Nossier

Authors
  1. N. M. Khalifa
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  2. E. S. Nossier
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  3. M. A. Al-Omar
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Correspondence to N. M. Khalifa.

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The text was submitted by the authors in English.

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Khalifa, N.M., Nossier, E.S. & Al-Omar, M.A. Synthesis and characterization of new pyrazolyl-substituted thiazolidinone, thiazole, and thiazoline candidates. Russ J Gen Chem 87, 1295–1299 (2017). https://doi.org/10.1134/S1070363217060263

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  • DOI: https://doi.org/10.1134/S1070363217060263

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