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Synthesis of some new pyrazolyl-thiazolidinone derivatives starting from 1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazole-4-carboxaldehyde

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Abstract

A novel synthetic approach to (E)-1-{[1-(3-chlorophenyl)-3-[(4-methoxyphenyl-1H-pyrazol-4-yl)- methylene]hydrazono}-3-phenylthiazolidin-4-one starting from the key intermediate thiosemicarbazone derivative is presented. The latter compound reacted with some aromatic and heterocyclic aldehydes to give (1-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methylene}hydrazono)-5-(substituted benzylidene)-3-phenylthiazolidin-4-one derivatives.

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Authors and Affiliations

  1. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Khalifa & M. A. Al-Omar

  2. Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki, Cairo, 12622, Egypt

    N. M. Khalifa

  3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt

    E. S. Nossier

Authors
  1. N. M. Khalifa
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  2. E. S. Nossier
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  3. M. A. Al-Omar
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Corresponding author

Correspondence to N. M. Khalifa.

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The text was submitted by the authors in English.

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Khalifa, N.M., Nossier, E.S. & Al-Omar, M.A. Synthesis of some new pyrazolyl-thiazolidinone derivatives starting from 1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazole-4-carboxaldehyde. Russ J Gen Chem 87, 868–872 (2017). https://doi.org/10.1134/S1070363217040338

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  • DOI: https://doi.org/10.1134/S1070363217040338

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