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Synthesis and characterization of some novel 1,3-diaryl pyrazole bearing 2-oxopyridine-3,5-dicarbonitrile derivatives

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Abstract

A series of new 1-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methyleneamino}-6-amino-1,2-dihydro-4-(substitutedphenyl)-2-oxopyridine-3,5-di carbonitrile derivatives (4a–4i) were synthesized and characterized via cyclization of the key intermediate (E)-N'-([1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methylene}-2-cyanoaceto hydrazide with different 2-arylidenemalononitrile.

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Authors and Affiliations

  1. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Khalifa & M. A. Al-Omar

  2. Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki, Cairo, 12622, Egypt

    N. M. Khalifa

  3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11754, Egypt

    E. S. Nossier

Authors
  1. N. M. Khalifa
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  2. M. A. Al-Omar
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  3. E. S. Nossier
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Corresponding author

Correspondence to N. M. Khalifa.

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The text was submitted by the authors in English.

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Khalifa, N.M., Al-Omar, M.A. & Nossier, E.S. Synthesis and characterization of some novel 1,3-diaryl pyrazole bearing 2-oxopyridine-3,5-dicarbonitrile derivatives. Russ J Gen Chem 87, 846–849 (2017). https://doi.org/10.1134/S1070363217040296

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  • DOI: https://doi.org/10.1134/S1070363217040296

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