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Synthesis and characterization of new acyclic nucleosides analogues derived from 2-phenyl quinoline candidates

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Abstract

Reaction of 4-substituted quinoline hydrazide with some aldohexoses and aldopentoses gave a series of new N-β-glycosides. The following cyclization of N-β-glycosides with acetic anhydride led to O-acetyl-[5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazol-2-yl]-D-glycosides. Structure of the newly synthesized products was elucidated by chemical and spectroscopic methods.

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References

  1. Perigaud, C., Gosselin, G., and Imbach, J.L., Nucleosides Nucleotides, 1992, vol. 11, p. 903. DOI: 10.1080/07328319208021748.

    Article  CAS  Google Scholar 

  2. Shaban, M.A. and Nasr, A.Z., Adv. Heterocycl. Chem., 1997, vol. 68, p. 223. DOI: 0065-2725/97.

    Article  CAS  Google Scholar 

  3. Shaban, M.A., Taha, M.A., and Morgaan, A.E., Monatsh. Chem., 2000, vol. 131, p. 487. DOI: 10.1007/PL00010316.

    CAS  Google Scholar 

  4. Suhadolnik, R.J., Nucleoside Antibiotics, New York: Wiley, 1970, p. 354.

    Google Scholar 

  5. Hoda, H.F., Khalifa, N.M., Eman, S.N., Mohamed, M.A., and Magda, M.F., Acta Poloniae Pharm. Drug Res., 2012, vol. 69, p. 411. PMID: 22594255.

    Google Scholar 

  6. Khalifa, N.M., Al-Omar, M.A., Amr, A.E., and Haiba, M.E., Int. J. Biol. Macromol., 2013, vol. 54, p. 51. DOI: 10.1016/jijbiomac.2012.11.015.

    Article  CAS  Google Scholar 

  7. Eweas, A.F., Khalifa, N.M., Ismail, N.S., Al-Omar, M.A., and Soliman, A.M., Med. Chem. Res., 2014, vol. 23, p. 76. DOI: 10.1007/s00044-013-0604-6.

    Article  CAS  Google Scholar 

  8. Ahmed, M.E., Omar, M.A., Khalifa, N.M., and Basma, S.G., Curr. Org. Chem., 2014, vol. 18, p. 629. DOI: 10.2174/13852728113176660134.

    Article  Google Scholar 

  9. Magda, M.F., Khalifa, N.M., Hoda, H.F., Eman, S.N., and Mohamed, M.A., J. Heterocycl. Chem., 2014, vol. 51, p. 450. 10.1002/jhet.1757.

    Article  Google Scholar 

  10. Khalifa, N.M., Ahmed, M.N., Al-Omar, M.A., and Amr, A.E., Z. Naturforsch. B, 2014, vol. 69, p. 728. DOI: 10.5560/ZNB.2014-4031.

    CAS  Google Scholar 

  11. Khalifa, N.M., Al-Omar, M.A., Amr, A.E., Ayman, R.B., and Rehab, F.A., Russ. J. Bioorg. Chem., 2015, vol. 41, p. 192. DOI: 10.1134/S1068162015020090.

    Article  CAS  Google Scholar 

  12. Haiba, M.E., Abdullah, E.S., Edrees, M.M., and Khalifa, N.M., Drug Res., 2015, vol. 65, p. 9. DOI: 10.1055/s-0034-1368721.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Pharmaceutical Chemistry Department, Drug Exploration and Development Chair, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Khalifa & M. A. Al-Omar

  2. Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki, Cairo, 12622, Egypt

    N. M. Khalifa

  3. Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    M. A. Al-Omar & A. E. Amr

  4. Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo, 12622, Egypt

    A. E. Amr

Authors
  1. N. M. Khalifa
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  2. M. A. Al-Omar
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  3. A. E. Amr
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Corresponding author

Correspondence to N. M. Khalifa.

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The text was submitted by the authors in English.

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Khalifa, N.M., Al-Omar, M.A. & Amr, A.E. Synthesis and characterization of new acyclic nucleosides analogues derived from 2-phenyl quinoline candidates. Russ J Gen Chem 86, 1115–1119 (2016). https://doi.org/10.1134/S1070363216050224

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  • DOI: https://doi.org/10.1134/S1070363216050224

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