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Crystal structure and anti-cancer activity of a novel mixed-ligand complex [Pd(Phen)(Phe)]Cl · H2O

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Abstract

A mixed-ligand complex [Pd(Phen)(Phe)]Cl·H2O (Phen-o-phenantroline, Phe-L-phenylalanine) is synthesized and structurally characterized by elemental analyses and single-crystal X-ray diffraction. Diffraction data: C21H19ClN3O3Pd, monoclinic, P21/n, a = 9.478(4) Å, b = 22.395(9) Å, c = 9.528 (4) Å, β = 104.358(11)°, V = 1959.3(14) Å3, Z = 4. The Pd atom has planar-square coordination geometry and is surrounded by the Phen and Phe ligand to form a monovalent complex cation, Cl− is filled in the crystal lattice as a counterion. The Cl atom is bonded to the complex cation through an electrostatic interaction and has a very weak hydrogen bond with a water molecule. Hydrogen bonding interactions and π-π stacking interactions stabilize the crystal lattice. The anti-cancer activity of the complex increases with the increasing concentration of the complex, which shows that the complex has strong anti-cancer activity.

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Authors and Affiliations

  1. Shenyang Institute of Chemical Technology, Shenyang, 110142, P.R. China

    E. J. Gao

  2. School of Chemical Science and Engineering, Liaoning University, Shenyang, 110016, P. R. China

    Q. T. Liu

  3. School of Pharmacautical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China

    L. Y. Duan

Authors
  1. E. J. Gao
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  2. Q. T. Liu
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  3. L. Y. Duan
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Gao, E.J., Liu, Q.T. & Duan, L.Y. Crystal structure and anti-cancer activity of a novel mixed-ligand complex [Pd(Phen)(Phe)]Cl · H2O. Russ J Coord Chem 33, 120–123 (2007). https://doi.org/10.1134/S107032840702008X

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  • DOI: https://doi.org/10.1134/S107032840702008X

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