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Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells

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Abstract

Targeted cationic liposomes containing folate lipoconjugates with spacer groups of various lengths and natures were prepared; their physicochemical characteristics and their transfection activity towards KB-3-1 and HEK 293 cells were determined. Targeted delivery of plasmid DNA was studied by competitive inhibition of DNA delivery in the presence of free folic acid.

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Funding

The work was financially supported by the Russian Science Foundation (project no. 18-73-00270).

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Authors and Affiliations

  1. Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University, 119571, Moscow, Russia

    E. V. Shmendel, N. G. Morozova & M. A. Maslov

  2. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    T. O. Kabilova & M. A. Zenkova

Authors
  1. E. V. Shmendel
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  2. T. O. Kabilova
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  3. N. G. Morozova
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  4. M. A. Zenkova
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  5. M. A. Maslov
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Corresponding author

Correspondence to M. A. Maslov.

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This article does not contain any studies involving animals or human participants performed by any of the authors.

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The authors declare that they have no conflict of interest.

Additional information

Translated by G. Levit

Abbreviations: 2X3, 1,26-bis(cholest-5-ene-3β-yloxycarbonylamino)-7,11,16,20-tetraazahexacosane tetrahydrochloride; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; EGFP, enhanced green fluorescent protein; FA, folic acid; FBS, fetal bovine serum; NAs, nucleic acids; pDNA, plasmid DNA.

Corresponding author: phone: +7 (499) 600-82-02; fax: +7 (495) 434-92-87; e-mail: mamaslov@mail.ru.

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Shmendel, E.V., Kabilova, T.O., Morozova, N.G. et al. Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells. Russ J Bioorg Chem 45, 719–725 (2019). https://doi.org/10.1134/S1068162019060360

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  • DOI: https://doi.org/10.1134/S1068162019060360

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