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The Use of Radioprotective Agents to Prevent Effects Associated with Aging

  • MODIFICATION OF RADIATION EFFECTS
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Abstract

Anti-aging properties can be found in many compounds with radiation-protective effects. Such compounds include the following: bioflavonoids, some antioxidants (N-acetylcysteine), melatonin, some non-steroid anti-inflammatory agents and statins, angiotensin converting enzyme inhibitors, metformin, rapamycin, etc. The effects of the drugs can develop both in the case of their long-term use and in case of a single application against the background of acute exposure to ionizing radiation at lethal doses. At the same time, “classical” radiation-protective agents such as cystamine, amifostine, adrenergic alfa-blockers, and androgenic drugs were not revealed to have geroprotective properties, which may be due to their high toxicity.

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  1. Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russia

    V. N. Bykov

  2. Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia

    A. N. Grebenyuk

  3. State Research Center, Burnasyan Federal Medical Biophysical Center of the Federal Medical Biological Agency, Moscow, Russia

    I. B. Ushakov

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Bykov, V.N., Grebenyuk, A.N. & Ushakov, I.B. The Use of Radioprotective Agents to Prevent Effects Associated with Aging. Biol Bull Russ Acad Sci 46, 1657–1670 (2019). https://doi.org/10.1134/S1062359019120021

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