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EPR Spectrometric Estimation of the Distribution of Intravenously Injected Nanodiamonds in Mice

  • HUMAN AND ANIMAL PHYSIOLOGY
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Abstract

The distribution in mice of intravenously injected modified nanodiamonds (MNDs) obtained by detonation synthesis was studied using electron paramagnetic resonance (EPR) spectrometry. It has been shown that 2.5 h after MND injection into the tail vein of mice, the nanoparticles accumulate mainly in the lungs and liver of animals; much smaller amounts of nanoparticles were found in the kidneys and heart. The presence of MNDs in the samples of blood, spleen, brain, and thigh muscles of mice was not detected within the sensitivity of the method used.

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Authors and Affiliations

  1. International Scientific Center for Studies of Extreme States of Organisms, Federal Research Center Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50, 660036, Krasnoyarsk, Russia

    E. V. Inzhevatkin & M. B. Volkova

  2. Institute of Biophysics, Federal Research Center Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50/50, 660036, Krasnoyarsk, Russia

    A. V. Baron, A. P. Puzyr & V. S. Bondar

  3. Siberian Federal University, pr. Svobodnyi 79, 660041, Krasnoyarsk, Russia

    A. V. Baron & M. B. Volkova

  4. Institute of Chemistry and Chemical Technology, Federal Research Center Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences, Akademgorodok 50/24, 660036, Krasnoyarsk, Russia

    N. G. Maksimov

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  1. E. V. Inzhevatkin
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  2. A. V. Baron
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  3. N. G. Maksimov
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  4. M. B. Volkova
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  5. A. P. Puzyr
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  6. V. S. Bondar
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Correspondence to E. V. Inzhevatkin.

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Translated by G. Levit

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Inzhevatkin, E.V., Baron, A.V., Maksimov, N.G. et al. EPR Spectrometric Estimation of the Distribution of Intravenously Injected Nanodiamonds in Mice. Biol Bull Russ Acad Sci 46, 277–283 (2019). https://doi.org/10.1134/S1062359019020079

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  • DOI: https://doi.org/10.1134/S1062359019020079

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