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Methods for the Determination of Selective Androgen Receptor Modulators

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Abstract

The history of the appearance and development of selective androgen receptor modulators (SARMs) is described. The main classes of SARMs and various approaches to their determination are considered. The use of chromatography–mass spectrometry is shown to be promising for the reliable determination of SARM traces in various samples. Well-known sample preparation and determination methods in biological materials are considered, and the metabolic pathways the best studied SARM (andarine) using cell cultures (in vitro) and laboratory animals and humans (in vivo) are compared.

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Funding

This study was supported by the Ministry of Higher Education and Science of the Russian Federation and the Russian Foundation for Basic Research (project no. 18-33-20009 mol_a_ved ) and carried out with the participation of specialists from the Environmental and Analytical Center of the Kuban State University (unique identifier RFMEFI59317Х0008).

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  1. Kuban State University, 350040, Krasnodar, Russia

    A. Z. Temerdashev & E. V. Dmitrieva

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  1. A. Z. Temerdashev
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  2. E. V. Dmitrieva
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Correspondence to E. V. Dmitrieva.

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Translated by V. Makhlyarchuk

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Temerdashev, A.Z., Dmitrieva, E.V. Methods for the Determination of Selective Androgen Receptor Modulators. J Anal Chem 75, 835–850 (2020). https://doi.org/10.1134/S1061934820070187

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  • DOI: https://doi.org/10.1134/S1061934820070187

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