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Protein microparticles with controlled stability prepared via layer-by-layer adsorption of biopolyelectrolytes

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Abstract

This review covers the experimental data on the preparation and characterization of protein microparticles with controlled stability that are formed by layer-by-layer adsorption of oppositely charged macromolecules. Variants of using proteins as adsorbed polyelectrolyes, methods of incorporating proteins into matrixes (aggregates and microspheres) for further deposition of biopolyelectrolytes, and immobilization of proteins in preformed multilayered polyelectrolyte particles due to a change in the permeability of their shells are considered. Special attention is given to biocompatible and biodegradable microparticles characterized by depot functions, that is, the ability to reliably protect biologically active compounds from aggregative media of the body and to quantitatively release protein preparations (hormones, enzymes, and peptides) into solution when a certain acidity of solution is attained. This feature is especially important for designing peroral means of protein delivery.

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  1. Faculty of Chemistry, Moscow State University, Moscow, 119991, Russia

    N. G. Balabushevich, V. A. Izumrudov & N. I. Larionova

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  1. N. G. Balabushevich
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Original Russian Text © N.G. Balabushevich, V.A. Izumrudov, N.I. Larionova, 2012, published in Vysokomolekulyarnye Soedineniya, Ser. A, 2012, Vol. 54, No. 7, pp. 1116–1129.

This work was supported by the Russian Foundation for Basic Research (project no. 10-03-00019-a) and the Fund of the Ministry of Education and Science of the Russian Federation (State contract 11.G34.31.0004).

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Balabushevich, N.G., Izumrudov, V.A. & Larionova, N.I. Protein microparticles with controlled stability prepared via layer-by-layer adsorption of biopolyelectrolytes. Polym. Sci. Ser. A 54, 540–551 (2012). https://doi.org/10.1134/S0965545X12040098

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