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The regional cerebral blood flow pattern of the normal human brain and its factor structure

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Abstract

The regional cerebral blood flow (rCBF) pattern of the normal human brain was drawn, and its structure was studied. Relative rCBF estimates for 66 regions of interest (cerebral anatomical-functional areas) were obtained using positron emission tomography in 158 healthy subjects aged 18–49 years. The rCBF rate variation range was 89–121% of the rCBF rate averaged over all regions of interest, taken as 100%. The rCBF rates were the highest (>115%) in the paracentral lobule, precuneus, insular cortex, primary visual cortex, and Broca’s area and the lowest (<95%) in the mediobasal regions of the temporal gyri and caudate nuclei. Analysis of the factor structure of the resultant pattern made it possible to classify cerebral anatomical-functional areas according to a predominant effect of one of the following factors on the interdependence between rCBF rates: (1) cytoarchitectonic characteristics; (2) the functional state of the cortex during quiet wakefulness; or (3) the brain vascular region to which the area belongs. The obtained pattern should be taken into account in both mapping of the functions of a normal brain and clinical diagnosis.

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Authors and Affiliations

  1. Institute of the Human Brain, Russian Academy of Sciences, St. Petersburg, 199164, Russia

    G. V. Kataeva & A. D. Korotkov

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  1. G. V. Kataeva
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  2. A. D. Korotkov
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Original Russian Text © G.V. Kataeva, A.D. Korotkov, 2007, published in Fiziologiya Cheloveka, 2007, Vol. 33, No. 4, pp. 5–10.

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Kataeva, G.V., Korotkov, A.D. The regional cerebral blood flow pattern of the normal human brain and its factor structure. Hum Physiol 33, 383–387 (2007). https://doi.org/10.1134/S0362119707040019

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