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Effect of Environmental Factors on Nuclear Organization and Transformation of Human B Lymphocytes

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Abstract

Chromosomal translocations have long been known for their association with malignant transformation, particularly in hematopoietic disorders such as B-cell lymphomas. In addition to the physiological process of maturation, which creates double strand breaks in immunoglobulin gene loci, environmental factors including the Epstein–Barr and human immunodeficiency viruses, malaria-causing parasites (Plasmodium falciparum), and plant components (Euphorbia tirucalli latex) can trigger a reorganization of the nuclear architecture and DNA damage that together will facilitate the occurrence of deleterious chromosomal rearrangements.

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Abbreviations

AICDA:

activation-induced cytosine deaminase

BL:

Burkitt lymphoma

CSR:

class switch recombination

DSBs:

DNA double strand breaks

EBV:

Epstein–Barr virus

HIV:

human immunodeficiency virus

NHEJ:

non-homologous end joining

RAG1(2):

recombination activating gene 1(2)

ROS:

reactive oxygen species

SHM:

somatic hypermutation

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. UMR8126, Université Paris-Sud, CNRS, Institut de Cancérologie Gustave Roussy, 94805, Villejuif, France

    F. B. Sall, D. Germini, A. P. Kovina, J. Wiels, M. Lipinski & Y. Vassetzky

  2. LIA1066 “Laboratoire Franco–Russe de Recherche en Oncologie”, 94805, Villejuif, France

    F. B. Sall, D. Germini, A. P. Kovina, J. Wiels, O. V. Iarovaia, M. Lipinski & Y. Vassetzky

  3. Laboratoire d’Hématologie Centre Hospitalier Universitaire Aristide Le Dantec, Université Cheikh Anta Diop, Dakar, Sénégal

    F. B. Sall & A. O. Toure

  4. Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    A. P. Kovina & O. V. Iarovaia

  5. Institut Gustave Roussy, 94805, Villejuif, France

    V. Ribrag

  6. Institut National de la Santé et de la Recherche Médicale (INSERM) Unité (U) 1009, Université Paris Sud, Institut Gustave Roussy, 94805, Villejuif, France

    V. Ribrag

  7. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    Y. Vassetzky

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  1. F. B. Sall
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Sall, F.B., Germini, D., Kovina, A.P. et al. Effect of Environmental Factors on Nuclear Organization and Transformation of Human B Lymphocytes. Biochemistry Moscow 83, 402–410 (2018). https://doi.org/10.1134/S0006297918040119

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  • DOI: https://doi.org/10.1134/S0006297918040119

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