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Mitochondrial production of reactive oxygen species

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Abstract

Numerous biochemical studies are aimed at elucidating the sources and mechanisms of formation of reactive oxygen species (ROS) because they are involved in cellular, organ-, and tissue-specific physiology. Mitochondria along with other cellular organelles of eukaryotes contribute significantly to ROS formation and utilization. This review is a critical account of the mitochondrial ROS production and methods for their registration. The physiological and pathophysiological significance of the mitochondrially produced ROS are discussed.

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Abbreviations

Amplex Red:

10-acetyl-3,7-dihydrophenoxazine

DLDH:

dihydrolipoamide dehydrogenase

DODH:

dihydroorotate dehydrogenase

ETF:

electron-transferring flavoprotein

GSSG and GSH:

oxidized and reduced forms of glutathione, respectively

MAO:

monoamine oxidase

mGPDH:

mitochondrial α-glycerophosphate dehydrogenase

NOX:

NAD(P)H oxidase

\(O_2^{\bar \cdot }\) and O sd2 H:

superoxide anion and its protonated form

·OH:

hydroxyl radical

OGDHc:

α-oxoglutarate dehydrogenase complex

PDHc:

pyruvate dehydrogenase complex

ROS:

reactive oxygen species

SMP:

submitochondrial particles

SOD:

superoxide dismutase

Δp:

proton electrochemical potential difference

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  1. Department of Biochemistry, Biological Faculty, Lomonosov Moscow State University, 119991, Moscow, Russia

    V. G. Grivennikova & A. D. Vinogradov

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  1. V. G. Grivennikova
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Published in Russian in Uspekhi Biologicheskoi Khimii, 2013, Vol. 53, pp. 245–296.

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Grivennikova, V.G., Vinogradov, A.D. Mitochondrial production of reactive oxygen species. Biochemistry Moscow 78, 1490–1511 (2013). https://doi.org/10.1134/S0006297913130087

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