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Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action

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Abstract

Lysophosphatidic acid (LPA) is a lipid mediator required for maintaining homeostasis of numerous physiological functions and also involved in development of some pathological processes through interactions with G protein-coupled receptors. Recently many data have appeared about the role of this phospholipid in humans, but pathways of LPA biosynthesis and mechanisms of its action remain unclear. This review presents modern concepts about biosynthesis, reception, and biological activity of LPA in humans. Natural and synthetic LPA analogs are considered in the view of their possible use in pharmacology as agonists and/or antagonists of G protein-coupled receptors of LPA.

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Abbreviations

ATX:

autotaxin

DAG:

diacylglycerol

GPC-receptors (GPCR):

G protein-coupled receptors

LPA:

lysophosphatidic acid

lysoPLD:

lysophospholipase D

MAPK:

mitogen-activated protein kinase

NPP:

nucleotide phosphatase/phosphodiesterase

PA:

phosphatidic acid

PLA1 :

phospholipase A1

PLA2 :

phospholipase A2

PLC:

phospholipase C

VEGF:

vascular endothelial growth factor

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Authors and Affiliations

  1. Vavilov Institute of General Genetics, Russian Academy of Sciences, ul. Gubkina 3, 119991, Moscow, Russia

    I. N. Berdichevets, T. V. Tyazhelova, Kh. R. Shimshilashvili & E. I. Rogaev

  2. Mental Health Research Center, Russian Academy of Medical Sciences, Zagorodnoe Shosse 2, 113122, Moscow, Russia

    E. I. Rogaev

  3. Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA, 01604, USA

    E. I. Rogaev

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  1. I. N. Berdichevets
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  2. T. V. Tyazhelova
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  3. Kh. R. Shimshilashvili
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  4. E. I. Rogaev
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Correspondence to I. N. Berdichevets.

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Original Russian Text © I. N. Berdichevets, T. V. Tyazhelova, Kh. R. Shimshilashvili, E. I. Rogaev, 2010, published in Biokhimiya, 2010, Vol. 75, No. 9, pp. 1213–1223.

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Berdichevets, I.N., Tyazhelova, T.V., Shimshilashvili, K.R. et al. Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action. Biochemistry Moscow 75, 1088–1097 (2010). https://doi.org/10.1134/S0006297910090026

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  • DOI: https://doi.org/10.1134/S0006297910090026

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