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“Smart” liposomal nanocontainers in biology and medicine

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Abstract

The perspectives of using liposomes for delivery of drugs to desired parts of the human body have been intensively investigated for more than 30 years. During this time many inventions have been suggested and different kinds of liposomal devices developed, and a number of them have reached the stages of preclinical or clinical trials. The latest techniques can be used to develop biocompatible nano-sized liposomal containers having some abilities of artificial intellect, such as the presence of sensory and responsive units. However, only a few have been clinically approved. Further improvements in this area depend on our knowledge of the interactions of drugs with the lipid bilayer of liposomes. Further studies on liposomal transport through the human body, their targeting of cells requiring therapeutic treatment, and finally, the development of techniques for controlled drug delivery to desired acceptors on cell surfaces or in cytoplasm are still required.

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Abbreviations

CHEMS:

cholesteryl hemisuccinate

DOPE:

dioleoyl phosphatidylethanolamine

DPPC:

dipalmitoyl phosphatidylcholine

DSPC:

distearoyl phosphatidylcholine

EPR:

enhanced permeability and retention

FR:

folate receptor

HePC:

hexadecyl phosphocholine

IR:

infrared light

OA:

oleic acid

PA:

phosphatidic acid

PC:

phosphatidylcholine

PE:

phosphatidylethanolamine

PEG:

polyethyleneglycol

PS:

phosphatidylserine

RES:

reticuloendothelial system

RFC:

reduced folate carrier

UV:

ultraviolet light

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  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia

    Y. S. Tarahovsky

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Published in Russian in Biokhimiya, 2010, Vol. 75, No. 7, pp. 920–935.

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Tarahovsky, Y.S. “Smart” liposomal nanocontainers in biology and medicine. Biochemistry Moscow 75, 811–824 (2010). https://doi.org/10.1134/S0006297910070023

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