Luminescent nanoparticles for molecular medicine

V. Weiler; M. Haase; C. Walter; W. Hoheisel; H. Hummel

doi:10.1117/12.729472

13 July 2007 Luminescent nanoparticles for molecular medicine

V. Weiler, M. Haase, C. Walter, W. Hoheisel, H. Hummel

Proceedings Volume 6633, Biophotonics 2007: Optics in Life Science; 66332J (2007) https://doi.org/10.1117/12.729472
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

Novel optical labels based on nanophosphor materials like LaPO₄:Ce,Tb and CePO₄:Tb-LaPO₄ core-shell nanophosphors were presented. Core particles could be synthesised smaller than 10nm and stabilized in aqueous media. Polymer coatings of individual nanoparticles increased long term stability and introduced functional groups of interest for bioconjugation chemistry. A new strategy for conjugation of bioligands via His-tags was given. In feasibility studies for in-vitro diagnostic applications these dnanophosphors featured their advantage over organic dyes. As an example the detection of hybridization and thermal induced denaturation events of DNA strands read out by FRET processes was presented.

Citation Download Citation

V. Weiler, M. Haase, C. Walter, W. Hoheisel, and H. Hummel "Luminescent nanoparticles for molecular medicine", Proc. SPIE 6633, Biophotonics 2007: Optics in Life Science, 66332J (13 July 2007); https://doi.org/10.1117/12.729472

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