Preparation and characterization of poly (ethylene glycol)-coated Stoeber silica nanoparticles for biomedical applications

Raoul Kopelman; Hao Xu; Fei Yan; Eric E. Monson; Wei Tang; Randy Schneider; Martin A. Philbert

doi:10.1117/12.472104

21 June 2002 Preparation and characterization of poly (ethylene glycol)-coated Stoeber silica nanoparticles for biomedical applications

Raoul Kopelman, Hao Xu, Fei Yan, Eric E. Monson, Wei Tang, Randy Schneider, Martin A. Philbert

Author Affiliations +

Proceedings Volume 4626, Biomedical Nanotechnology Architectures and Applications; (2002) https://doi.org/10.1117/12.472104
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Monodisperse, spherical, polyethylene glycol (PEG)-coated silica nanoparticles have been prepared in the size range of 50-350 nm, and their size distribution were characterized by SEM and multi-angle static light scattering experiments. The chemical binding of PEG to the silica nanoparticles was confirmed by IR spectroscopy. The biocompatibility of these PEGylated nanoparticles was also studied by non-specific protein binding tests and in-vivo toxicology studies in live animals. These silica nanoparticles, as a matrix for encapsulation of certain reagents, have been used for the fabrication of intracellular sensors and have potential for applications to in vivo diagnosis, analysis and measurements, due to their small physical size and their biocompatibility, both stemming from the specialized PEG coating.

Citation Download Citation

Raoul Kopelman, Hao Xu, Fei Yan, Eric E. Monson, Wei Tang, Randy Schneider, and Martin A. Philbert "Preparation and characterization of poly (ethylene glycol)-coated Stoeber silica nanoparticles for biomedical applications", Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); https://doi.org/10.1117/12.472104

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