Facile synthesis of fluorescent carbon quantum dots and their potential application in cancer theranostics

Bryan Christian A. Karingal; Yih-Chih Hsu

doi:10.1117/12.2584203

5 March 2021 Facile synthesis of fluorescent carbon quantum dots and their potential application in cancer theranostics

Bryan Christian A. Karingal, Yih-Chih Hsu

Proceedings Volume 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII; 116600C (2021) https://doi.org/10.1117/12.2584203
Event: SPIE BiOS, 2021, Online Only

Abstract

Carbon quantum dots (CQDs) are an emerging research area in the biomedical field due to their biocompatibility and multifunctionality. Herein, we report CQDs synthesized in a green, fast, facile manner in a recyclable mineral oil-mediated pyrolysis medium using citric acid as the main carbon source and thiourea as N- and S-doping source. The assynthesized CQDs exhibit excitation-dependent photoemission (Φ = 0.57) with notable energy upconversion behavior at longer wavelengths, suggesting possible utilization in multiphoton microscopy. FT-IR characterization suggest diverse functional groups on the surface which include carboxylic acids, amines, and thiocyanates among others. Photothermal analysis supported the NIR-emissive behavior and showed that CQD solution temperature could potentially increase nearly 20°C higher after 10 min irradiation by 630-nm LED laser source powered at 1 W/cm2. CQDs have been tested in vitro and has been used as multicolor cellular imaging agent.

Conference Presentation

Citation Download Citation

Bryan Christian A. Karingal and Yih-Chih Hsu "Facile synthesis of fluorescent carbon quantum dots and their potential application in cancer theranostics", Proc. SPIE 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII, 116600C (5 March 2021); https://doi.org/10.1117/12.2584203

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