Reactive oxygen species explicit dosimetry for Photofrin-mediated pleural photodynamic therapy

Yi Hong Ong; Michele M. Kim; Andrea Dimofte; Arjun G. Yodh; Sunil Singhal; Keith Cengel; Theresa M. Busch; Timothy C. Zhu

doi:10.1117/12.2525619

7 August 2019 Reactive oxygen species explicit dosimetry for Photofrin-mediated pleural photodynamic therapy

Yi Hong Ong, Michele M. Kim, Andrea Dimofte, Arjun G. Yodh, Sunil Singhal, Keith Cengel, Theresa M. Busch, Timothy C. Zhu

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 11070B0 (2019) https://doi.org/10.1117/12.2525619
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Reactive oxygen species explicit dosimetry (ROSED) has been recently developed and demonstrated to be able to better correlate with treatment outcome in both preclinical type I and type II PDT. ROSED involves direct measurements of in-vivo light fluence (rate), invivo photosensitizer concentration and tissue oxygenation to calculate for reacted ROS concentration ([ROS]rx) generated by PDT processes. In this study, we demonstrated ROSED in an ongoing Phase II clinical trial of Photofrin-mediated PDT for pleural mesothelioma [1]. We measured light fluence rate and PS concentration using isotropic detectors and tissue blood flow using DCS contact probes that are sutured on the pleural cavity wall. 7 patients were measured during the period of 2016-2018, which includes 2 patients with one DCS measurement location and 5 patients with two DCS measurements on different locations on the pleural cavity wall. Different dose metrics, including light fluence, PDT dose and [ROS]rx calculated based on light fluence, photosensitizer concentration, and blood flow were compared.

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Yi Hong Ong, Michele M. Kim, Andrea Dimofte, Arjun G. Yodh, Sunil Singhal, Keith Cengel, Theresa M. Busch, and Timothy C. Zhu "Reactive oxygen species explicit dosimetry for Photofrin-mediated pleural photodynamic therapy", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070B0 (7 August 2019); https://doi.org/10.1117/12.2525619

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KEYWORDS

Photodynamic therapy

Oxygen

Radiation oncology

Chest

In vivo imaging

Optical testing

Tissue optics

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