Laser induced heating of PMMA microspheres for remote drug release: a FEM simulation model

Henrique Vilhena; João M. P. Coelho; José M. Rebordão

doi:10.1117/12.2063448

22 August 2014 Laser induced heating of PMMA microspheres for remote drug release: a FEM simulation model

Henrique Vilhena, João M. P. Coelho, José M. Rebordão

Proceedings Volume 9286, Second International Conference on Applications of Optics and Photonics; 92862H (2014) https://doi.org/10.1117/12.2063448
Event: Second International Conference on Applications of Optics and Photonics, 2014, Aveiro, Portugal

Abstract

We present a model in which polymeric spherical microstructures embedded with a light absorbing dye are shown to attain the phase transition temperature necessary for the release of a drug contained in its polymeric matrix into the surrounding medium. By numerically solving the heat diffusion equation and considering a Gaussian near-infrared source it is shown that heating is mostly confined to the particle although limited heat transfer occurs out into the surrounding medium. The influence of different operational parameters is analyzed. Based on the results, we elaborate on the experimental implementation of this kind of remotely operated drug delivery systems.

Citation Download Citation

Henrique Vilhena, João M. P. Coelho, and José M. Rebordão "Laser induced heating of PMMA microspheres for remote drug release: a FEM simulation model", Proc. SPIE 9286, Second International Conference on Applications of Optics and Photonics, 92862H (22 August 2014); https://doi.org/10.1117/12.2063448

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