Evanescent-wave infrared fiber optic biosensor

L. Pierre de Rochemont; Nancy W. Downer; Timothy E. May; H. Gilbert Smith; Carlton E. Oakes; Marc E. Ertan-Lamontagne

doi:10.1117/12.143548

30 April 1993 Evanescent-wave infrared fiber optic biosensor

L. Pierre de Rochemont, Nancy W. Downer, Timothy E. May, H. Gilbert Smith, Carlton E. Oakes, Marc E. Ertan-Lamontagne

Proceedings Volume 1796, Chemical, Biochemical, and Environmental Fiber Sensors IV; (1993) https://doi.org/10.1117/12.143548
Event: Fibers '92, 1992, Boston, MA, United States

Abstract

An infrared fiber-optic neurotoxin biosensor was constructed by applying a biologically active cladding to the core of an infrared transmitting chalcogenide fiber. Binding of the surface bound receptor protein was monitored by performing infrared difference spectroscopy on the fiber-optic probe before and after its exposure to various concentrations of neurotoxin in solution. Signals measuring conformational change(s) as a result of these interactions are observed to saturate in agreement with established biochemical kinetics for the receptor. Fiber-optic components are shown to be much more sensitive than bulk optical components in performing these measurements.

Citation Download Citation

L. Pierre de Rochemont, Nancy W. Downer, Timothy E. May, H. Gilbert Smith, Carlton E. Oakes, and Marc E. Ertan-Lamontagne "Evanescent-wave infrared fiber optic biosensor", Proc. SPIE 1796, Chemical, Biochemical, and Environmental Fiber Sensors IV, (30 April 1993); https://doi.org/10.1117/12.143548

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