Novel coaxial atomization processes for microfabrication of multi-layered biodegradable microcapsules

Ting Si; Leilei Zhang; Guangbin Li; Ronald Xu

doi:10.1117/12.1000022

11 December 2012 Novel coaxial atomization processes for microfabrication of multi-layered biodegradable microcapsules

Ting Si, Leilei Zhang, Guangbin Li, Ronald Xu

Proceedings Volume 8553, Optics in Health Care and Biomedical Optics V; 85531H (2012) https://doi.org/10.1117/12.1000022
Event: Photonics Asia, 2012, Beijing, China

Abstract

Experimental and theoretical studies on coaxial atomization process of fabricating multifunctional microcapsules were performed to overcome the limitation of commonly used microfabrication processes. The coaxial electrospray was first developed, and then a novel process named coaxial electro-flow focusing which combined coaxial electrospray with coaxial flow focusing was proposed. The process was characterized by the formation of a coaxial liquid jet in the core of a high-speed co-flowing gas stream under an axial electric field and the breakup of the liquid jet into fine microcapsules. The effects of main process parameters on the meniscus attached to the mouth of the coaxial needle were tested. A theoretical model was further implemented for instability analysis of the coaxial jet to guide the process control and optimization. As a result, stable cone-jet configurations in a wide range of process parameters and microcapsules with good morphologies were obtained. The reported research represents the first step toward quantitative control and optimization of the coaxial atomization process for the microfabrication of multifunctional microcapsules in multimodal imaging and image-guided therapy.

Citation Download Citation

Ting Si, Leilei Zhang, Guangbin Li, and Ronald Xu "Novel coaxial atomization processes for microfabrication of multi-layered biodegradable microcapsules", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85531H (11 December 2012); https://doi.org/10.1117/12.1000022

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