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Anti-allergic effects of the brown alga Eisenia arborea on Brown Norway rats

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Abstract

To investigate the anti-allergic effects of the brown alga Eisenia arborea. A strain of Brown Norway rats know to strongly respond to immunoglobulin E (IgE) were used as an allergy model animal. The rats were immunized with ovalbumin by oral administration. The levels of serum IgE and histamine were suppressed in the rats fed a diet supplemented with dried E. arborea powder. As for the cytokine pattern, the interferon-γ production in the spleens and mesenteric lymph nodes (MLN) was enhanced, and the interleukin-4 (IL-4) production in the spleens and/or IL-10 production in the spleens and MLN were suppressed. These results, together with the change in the Th1/Th2 balance, indicate that the rats fed with E. arborea became more anti-allergic, suggesting that E. arborea might possess anti-allergic effects.

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Authors and Affiliations

  1. Product Development Department, Kanehatsu Food Co., Ltd, Minami Nagoya, 457-8555, Aichi, Japan

    Yoshimasa Sugiura, Kohji Matsuda & Takashi Okamoto

  2. Laboratory of Marine Biochemistry, Graduate School of Bioresources, Mie University, 514-8507, Tsu, Mie, Japan

    Yoshimasa Sugiura, Makoto Kakinuma & Hideomi Amano

Authors
  1. Yoshimasa Sugiura
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  2. Kohji Matsuda
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  3. Takashi Okamoto
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  4. Makoto Kakinuma
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  5. Hideomi Amano
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Correspondence to Makoto Kakinuma.

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Sugiura, Y., Matsuda, K., Okamoto, T. et al. Anti-allergic effects of the brown alga Eisenia arborea on Brown Norway rats. Fish Sci 74, 180–186 (2008). https://doi.org/10.1111/j.1444-2906.2007.01508.x

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  • DOI: https://doi.org/10.1111/j.1444-2906.2007.01508.x

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