Hydrodynamic Focusing on a Silicon Chip: Mixing Nanoliters in Microseconds

James B. Knight, Ashvin Vishwanath, James P. Brody, and Robert H. Austin
Phys. Rev. Lett. 80, 3863 – Published 27 April 1998
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Abstract

We describe the formation and control of nanoscale, submerged fluid jets. The focusing process necessary to achieve these small length scales is characterized experimentally and theoretically. Fast mixing is one important application of nanoscale fluid control: We demonstrate this with a continuous-flow mixer capable of mix times of less than 10μs and sample consumption rates of nanoliters per second. This new technique facilitates the study of fast reaction kinetics on time scales unattainable with conventional mixing technology.

  • Received 4 November 1997

DOI:https://doi.org/10.1103/PhysRevLett.80.3863

©1998 American Physical Society

Authors & Affiliations

James B. Knight, Ashvin Vishwanath, James P. Brody, and Robert H. Austin

  • Department of Physics, Princeton University, Princeton, New Jersey 08544

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Issue

Vol. 80, Iss. 17 — 27 April 1998

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