Regulation of Cellular and Humoral Immune Responses by T-cell Subclasses
This extract was created in the absence of an abstract.
Excerpt
It has become increasingly clear that both the type and intensity of the immune response to antigen are controlled by a complex series of interactions among different types of T lymphocytes and macrophages. This conclusion comes from several lines of experiments. First, studies of the cellular basis of the immune response have indicated that T cells are capable of both helper-initiator, suppressive, and cytolytic effects, and that these activities are specialized functions of distinct subclasses of T cells (Shiku et al. 1975; Cantor and Boyse 1975a,b; Cantor et al. 1976; Jandinski et al. 1976; Huber et al. 1976). Studies of the genetic control of the immune response have also indicated that the intensity of both antibody- and cell-mediated immune reactivity to many antigens is under strict H-linked (Ir) genetic control (McDevitt and Benacerraf 1969; Benacerraf and McDevitt 1972), reflecting either preferential induction of suppressive T lymphocytes (Kapp et al. 1974;...
