Studies on the Epstein-Barr Virus Genome and the EBV-determined Nuclear Antigen in Human Malignant Disease
This extract was created in the absence of an abstract.
Excerpt
EBV is known to cause infectious mononucleosis (Henle and Henle 1972) and to convert normal human and other primate lymphocytes of the B-type into established lines with unlimited capacity for continuous division (Miller 1971). A malignant potential has been demonstrated in such lines by heterotransplantation (Adams et al. 1967, 1970; Levin et al. 1969; Southam et al. 1969) or, in non-human primates, by autotransplantation (Leibold, unpubl.). In marmoset and owl monkeys, the virus can induce lymphoreticular malignancies directly (Epstein et al. 1973; Miller et al. 1974; Shope et al. 1973).
The role of EBV in human malignancy is less clear. The purpose of this paper is to examine this role in the light of some recent information concerning the presence of the viral genome in certain human malignancies in vivo.
Research on EBV has developed from serological approaches. The etiological role of the virus in infectious mononucleosis was established through...
