Effect of the type of hydrophobic polymers on the size of nanoparticles obtained by emulsification–solvent evaporation

https://doi.org/10.1070/MC2003v013n02ABEH001690Get rights and content

The effect of the molecular structure of hydrophobic polymers on their interfacial activity at the methylene chloride–water interface, as well as on the emulsifying ability and the size of nanoparticles obtained by emulsification–solvent evaporation, has been studied.

References (9)

  • M. Hombreiro Perez et al.

    J. Control. Release

    (2000)
  • M. Leroueil-Le Verger et al.

    Eur. J. Pharm. Biopharm.

    (1998)
  • S. Gibaud et al.

    J. Pharm. Sci.

    (1996)
  • F. Boury et al.

    J. Colloid Interface Sci.

    (1995)
There are more references available in the full text version of this article.

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