Asthma, Rhinitis, Other Respiratory DiseasesIntranasal heparin reduces eosinophil recruitment after nasal allergen challenge in patients with allergic rhinitis☆
Section snippets
Subjects
We studied 10 subjects (3 male and 7 female) aged 18 to 40 years (mean age ± SD, 31.3 ± 10.2 years), each with an obvious history of allergic rhinitis. Allergic rhinitis was defined by a positive cutaneous prick test result and a positive RAST result of class 3 or 4. Patients with allergic rhinitis had seasonal symptoms; all patients were allergic to Parietaria judaica (10 patients). None had nasal polyposis, chronic nasal obstruction, or other serious illness.
No subject was admitted to the
Symptom scores
As expected, nasal challenge with increasing concentration of allergen resulted in immediate symptoms in all subjects. All patients completed the study, and no severe adverse reactions during the nasal lavage and challenge procedures were noted. Results, given as mean nasal symptom scores after allergen challenge following treatment with heparin or saline solution, are presented in Fig 1.
Discussion
In patients with allergic rhinitis, nasal antigen challenge has been successfully used to monitor allergic inflammatory responses during both the EPR and the LPR.22, 23 Mast cells are crucial for the development of EPR; in contrast, eosinophils are considered the most prominent effector cells in the LPR, and their role in the pathogenesis of allergic diseases is believed to be critical. Eosinophils are in fact able to produce a wide array of proinflammatory cytokines and have the capacity to
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Reprint requests: Carlo Vancheri, MD, PhD, Institute of Respiratory Diseases, University of Catania, Via Passo Gravina, 187 95125-Catania, Italy.