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Thromb Haemost 1994; 72(06): 979-984
DOI: 10.1055/s-0038-1648993
Original Article
Schattauer GmbH Stuttgart

Increased Levels of Soluble Adhesion Molecules in Type 2 (Non-Insulin Dependent) Diabetes mellitus Are Independent of Glycaemic Control

M Steiner
1   The University of Rostock, Institute of Clinical Chemistry and Pathobiochemistry, Rostock, Germany
,
K M Reinhardt
1   The University of Rostock, Institute of Clinical Chemistry and Pathobiochemistry, Rostock, Germany
,
B Krammer
1   The University of Rostock, Institute of Clinical Chemistry and Pathobiochemistry, Rostock, Germany
,
B Ernst
1   The University of Rostock, Institute of Clinical Chemistry and Pathobiochemistry, Rostock, Germany
,
A D Blann
2   Department of Surgery, University Hospital of South Manchester, Didsbury, Manchester, UK
› Author Affiliations
Further Information

Publication History

Received 30 May 1994

Accepted after revision 08 August 1994

Publication Date:
06 July 2018 (online)

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Summary

Patients with Type 2 (non-insulin dependent) diabetes mellitus are at increased risk of thrombosis and the premature development of atherosclerosis. This may be related to damage to the endothelium (which may be the primary target tissue for the disease process) resulting from a loss of normal glycaemic metabolic control. Thus changes in endothelial cell function, such as modified release of soluble leukocyte and platelet adhesion molecules, may be important. Accordingly, E-selec-tin, von Willebrand factor (vWf), vascular cell adhesion molecule (VCAM) and intercellular adhesion molecule (ICAM) were measured in serum from 60 patients and 76 controls. Raised levels of vWf (p = 0.0002), E-selectin (p <0.0001) and VC AM (p = 0.003) in patient’s samples failed to correlate with glycaemic control as assessed by levels of fructosamine and glycated haemoglobin, or with 24 h urine albumin. Levels of ICAM were not increased in our patients. Levels of the two endothelial cell products, vWf and E-selectin, failed to correlate although E-selectin correlated with low density lipoprotein cholesterol (p = 0.016). vWf correlated with VCAM (p <0.001) and hypertension (p = 0.032). We conclude that levels of soluble adhesion molecules vWf, E-selectin and VCAM are raised in Type 2 diabetes mellitus. The mechanisms for these changes appear to be independent of glycaemic control but may relate to concurrent hypertension and/or hypercholes-terolaemia.

 

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