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DOI: 10.1055/s-0028-1093708
© Georg Thieme Verlag KG Stuttgart · New York
The Lipoprotein Lipase Activity of Brown Adipose Tissue during Early Post-Natal Development of the Normal and Hypothyroid Rat.
Publication History
Publication Date:
23 December 2008 (online)
Abstract
The heparin-releasable LP lipase activity of BAT (brown adipose tissue), and the TG (triglyceride) content of plasma were determined in normal and hypothyroid rats during early post-natal development. The TG content of plasma increased sharply after the onset of suckling and decreased during the weaning period in normal rats, while it stayed at a high level in hypothyroid rats. LP lipase activity was maximal during the perinatal period and decreased later, being practically undetectable in one month old control animals; in contrast, LP lipase activity was still present in cretin rats at this age.
The effects of several forms of treatment were also tested in weaned rats: a high-fat diet was not able to maintain the high LP lipase activity of suckling rats, but the activity was high if the animals were bred at a cold temperature. Thyroxine injections had no effect.
These results are discussed in terms of the possible factors regulating the LP lipase activity in BAT.
Key words
Brown Adipose Tissue - LP Lipase Activity - Post-Natal Development - Hypothyroidism - Cold Response