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Horm Metab Res 1985; 17(11): 551-553
DOI: 10.1055/s-2007-1013604
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© Georg Thieme Verlag, Stuttgart · New York

The Relationship between Plasma Concentration and Disappearance Rate of Immunoreactive Insulin in the Conscious Dog

R. W. Stevenson, A. D. Cherrington, K. E. Steiner
  • Department of Physiology, Vanderbilt University Medical School, Nashville, Tennessee, U.S.A.
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Publication History

1984

1984

Publication Date:
14 March 2008 (online)

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Summary

The relationship between plasma concentration and disappearance (infusion) rate of insulin was determined during infusion of insulin via the portal circulation of 14 normal euglycaemic dogs when somatostatin was infused to block endogenous insulin secretion. The relationship could be represented by one straight line over the plasma immunoreactive insulin range 0 to 110 μ/ml (r = 0.99) but above 110 μ/ml the fractional insulin disappearance rate declined. The results indicate the existence in the dog of a saturable pathway of insulin degradation that could conceivably be located in liver and which may become saturated only at insulin concentrations in the portal vein exceeding approximately 330 μ/ml.

Key-Words:

Insulin - Disappearance Rate - Dog

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