Studies on Cardio-Active Crude Drugs; I. Effect of Coumarins on Cultured Myocardial Cells

Tsuneo Namba; Osamu Morita; Sheng-Lun Huang; Kiyota Goshima; Masao Hattori; Nobuko Kakiuchi

doi:10.1055/s-2006-962432

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Planta Med 1988; 54(4): 277-282
DOI: 10.1055/s-2006-962432

Papers

Studies on Cardio-Active Crude Drugs; I. Effect of Coumarins on Cultured Myocardial Cells

Tsuneo Namba¹ , Osamu Morita¹ , Sheng-Lun Huang¹ , Kiyota Goshima² , Masao Hattori¹ , Nobuko Kakiuchi¹

¹Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Toyama, 930-01, Japan.
²Faculty of Science, Nagoya University, Chikusa-ku, Nagoya 464, Japan.

Further Information

Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

Using cultured embryonic myocardial cells, the effects of naturally occurring coumarins with various types of structures on the beating activity were studied. Coumarins isolated from Angelica decursiva Fr. et Sav., Umbelliferae, decursinol and nodakenetin, as well as dicoumarol, one of the known anticoagulants, remarkably decreased beating rate of the cells. The inhibitory effect on the beating rate was in parallel to calcium uptake, suggesting that the inhibition of myocardial cell beating was due to blocking of calcium influx.

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