Antiplasmodial Flavonoids from Erythrina sacleuxii

 

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Abstract

The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4′-methoxy-3′-prenylisoflavone (trivial name 5-deoxy-3′-prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sacleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence.

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Abiy Yenesew

Department of Chemistry

University of Nairobi

P.O. Box 30197

Nairobi

Kenya

Phone: +254-20-444-9004 ext 2170

Fax: +254-20-4446138

Email: ayenesew@uonbi.ac.ke