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Synthesis 1993; 1993(3): 290-292
DOI: 10.1055/s-1993-25849
short paper
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A Safe, Economical Method for the Preparation of ß-Oxo Esters

Ronald J. Clay* , Thomas A. Collom, Gregory L. Karrick, James Wemple
  • *Parke-Davis Pharmaceutical Research Division, Warner Lambert Company, Chemical Development Department, Holland, Michigan 49424, USA
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Publication History

Publication Date:
17 September 2002 (online)

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A high yield, economical method for preparation of ß-oxo esters has been developed involving the reaction of acid chlorides with potassium ethyl malonate using a magnesium chloride-triethylamine base system in either acetonitrile or ethyl acetate solvents. The method is suitable for the preparation of high purity ß-oxo esters in the laboratory and also in large scale production.

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