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DOI: 10.1055/s-0031-1282648
Effect of Urtica dioica on proliferation of HCT-116 colon cancer cell line
Urtica dioica L. (stinging nettle), a member of the Urticaceae family is a plant which has been used as a remedy for diabetes mellitus (1), benign prostatic hyperplasia (2), arthritis (3), allergic rhinitis (4), hypertension and cardiovascular disease (5). In recent studies it was shown that extract of Urtica dioica exhibited significant growth reduction in human prostatic epithelial cells (6) and inhibition on adenosine deaminase activity in prostate tissue. In this study we aimed to investigate the effect of Urtica dioica on proliferation of HCT-116 colon cancer cell line. Herbal preparation of Urtica dioica was made by ethanol extraction which was followed by evaporation. HCT-116 cells were incubated with different doses of Urtica dioica ranging from 3,33mg/mL to 42,8mg/mL for 24 hours. Cell viability was measured with MTT test. Results showed that Urtica dioica (33,3mg/mL, 42,8mg/mL) inhibited HCT-116 colon cancer cell proliferation significantly (p<0,001). Further studies are needed to reveal the effectiveness of Urtica dioica as an alternative therapy for colon cancer.
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