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Synthesis 2010(15): 2599-2603  
DOI: 10.1055/s-0029-1218819
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Highly Efficient One-Pot Synthesis of N-Acylsulfonamides Using Cyanuric Chloride at Room Temperature

Mohammad Navid Soltani Rad*a, Ali Khalafi-Nezhad*b, Zeinab Asrarib, Somayeh Behrouzb
a Department of Chemistry, Faculty of Basic Sciences, Shiraz University of Technology, Shiraz 71555-313, Iran
Fax: +98(711)7354523; e-Mail: soltani@sutech.ac.ir; e-Mail: nsoltanirad@gmail.com;
b Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
Further Information

Publication History

Received 5 March 2010
Publication Date:
17 June 2010 (online)

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Abstract

A highly efficient and very mild one-pot synthesis of N-acylsulfonamides is described using cyanuric chloride. In this synthesis, structurally diverse carboxylic acids and sulfonamides are reacted in the presence of cyanuric chloride, triethylamine, and alumina in anhydrous acetonitrile at room temperature to afford various N-acylsulfonamides in excellent yields.

Key words

one-pot - N-acylsulfonamide - sulfonamide - carboxylic acid - cyanuric chloride

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